Journal of Korean Society of Health-System Pharmacists

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Table. 2.

Table. 2.

Frequent contraindicated drug-drug interaction (Top 20)

Between prescriptions Inpatient(n=12,972) n (%) Outpatient(n=1,407) n (%)
1 Potassium chloride-Spironolactone 2,183 (16.8) Calcitriol-Paricalcitol 121 (8.6)
2 Diclofenac-Ketorolac 1,817 (14.0) Escitalopram-Hydroxyzine 113 (8.0)
3 Ephedrine-Epinephrine 1,369 (10.6) Iohexol-Metformin 105 (7.5)
4 Norepinephrine-Salbutamol 938 (7.2) Spironolactone-Tacrolimus 73 (5.2)
5 Buprenorphine-Morphine 864 (6.7) Hydroxyzine-Levofloxacin 62 (4.4)
6 Aspirin-Ketorolac 718 (5.5) Potassium chloride-Spironolactone 50 (3.6)
7 Furosemide-Gentamicin 411 (3.2) Iohexol-Sitagliptin/Metformin 40 (2.8)
8 Spironolactone-Tacrolimus 379 (2.9) Buprenorphine-Morphine 37 (2.6)
9 Epinephrine-Salbutamol 341 (2.6) Domperidone-Metoclopramide 37 (2.6)
10 Iodixanol-Metformin 329 (2.5) Sildenafil-Tadalafil 32 (2.3)
11 Meropenem-Valproic acid 309 (2.4) Nicorandil-Tadalafil 30 (2.1)
12 Hydroxyzine-Levofloxacin 263 (2.0) Cyclosporine-Tacrolimus 28 (2.0)
13 Ephedrine-Norepinephrine 261 (2.0) Amiodarone-Hydroxyzine 26 (1.8)
14 Iodixanol-Sitagliptin/Metformin 176 (1.4) Domperidone-Escitalopram 24 (1.7)
15 Epinephrine-Quetiapine 138 (1.1) Cyclosporine-Dabigatran 22 (1.6)
16 Amiodarone-Hydroxyzine 134 (1.0) Amiodarone-Sotalol 21 (1.5)
17 Epinephrine-Isoproterenol 133 (1.0) Nitroglycerin-Tadalafil 20 (1.4)
18 Iopromide-Metformin 125 (1.0) Nicorandil-Sildenafil 19 (1.4)
19 Isoproterenol-Norepinephrine 124 (1.0) Hydroxyzine-Moxifloxacin 19 (1.4)
20 Haloperidol-Hydroxyzine 117 (0.9) Atorvastatin-Itraconazole 18 (1.3)
기타 1,843 (14.2) 기타 510 (36.2)
Within one prescription Inpatient(n=7,024) n (%) Outpatient(n=1,136) n (%)
1 Diclofenac-Ketorolac 2,276 (32.4) Spironolactone-Tacrolimus 170 (15.0)
2 Potassium chloride-Spironolactone 992 (14.1) Sildenafil-Tadalafil 107 (9.4)
3 Norepinephrine-Salbutamol 658 (9.4) Potassium chloride-Spironolactone 97 (8.5)
4 Spironolactone-Tacrolimus 383 (5.5) Mirodenafil-Tadalafil 58 (5.1)
5 Ephedrine-Norepinephrine 270 (3.8) Mirodenafil-Sildenafil 56 (4.9)
6 Domperidone-Metoclopramide 255 (3.6) Mirodenafil-Udenafil 50 (4.4)
7 Meropenem-Valproic acid 245 (3.5) Tadalafil-Udenafil 45 (4.0)
8 Aspirin-Ketorolac 216 (3.1) Avanafil-Udenafil 43 (3.8)
9 Hydroxyzine-Levofloxacin 176 (2.5) Avanafil-Mirodenafil 43 (3.8)
10 Ephedrine-Epinephrine 156 (2.2) Sildenafil-Udenafil 41 (3.6)
11 Fluconazole-Triazolam 129 (1.8) Avanafil-Sildenafil 35 (3.1)
12 Epinephrine-Isoproterenol 110 (1.6) Buprenorphine-Morphine 33 (2.9)
13 Isoproterenol-Norepinephrine 96 (1.4) Avanafil-Tadalafil 33 (2.9)
14 Itraconazole-Triazolam 82 (1.2) Hydroxyzine-Levofloxacin 32 (2.8)
15 Furosemide-Gentamicin 76 (1.1) Azathioprine-Febuxostat 24 (2.1)
16 Nitroglycerin-Sildenafil 58 (0.8) Amiloride-Potassium chloride 21 (1.8)
17 Haloperidol-Hydroxyzine 56 (0.8) Isosorbide mononitrate-Sildenafil 15 (1.3)
18 Atorvastatin-Itraconazole 49 (0.7) Bosentan-Tacrolimus 13 (1.1)
19 Hydroxyzine-Moxifloxacin 49 (0.7) Alfacalcidol-Calcitriol 12 (1.1)
20 Alprazolam-Itraconazole 48 (0.7) Escitalopram-Hydroxyzine 11 (1.0)
기타 644 (9.2) 기타 197 (17.3)
J. Kor. Soc. Health-syst. Pharm. 2021;38:291-305 https://doi.org/10.32429/jkshp.2021.38.3.001
© 2021 J. Kor. Soc. Health-syst. Pharm.