Journal of Korean Society of Health-System Pharmacists

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Table. 2.

Table. 2.

Risk factors for developing bacteremia resistant to ceftizoxime/amikacin in hematologic disease patients with bacteremic neutropenic fever after chemotherapy

Characteristics Univariate Multivariate
OR (95% CI) P-Value OR (95% CI) P-Value
Steroid use* 2.0(1.03~4.21) 0.039 NS
Antibiotics exposure*
3rd generation cephalosporin 2.8(1.40~5.82) 0.003 2.5(1.23~5.31) 0.012
Piperacillin/tazobactam 2.2(1.10~4.72) 0.024 2.1(1.01~4.58) 0.048
Fluoroquinolone 1.7(0.89~3.47) 0.101 NS
Other beta-lactams 2.0(0.73~5.50) 0.166 NS

NS; not significant

Variables with p-Valve <0.2 from the univariate analyses were selected into the multivariate logistic regression model.

Variables adjusted in the model include steroid use, antibiotic exposure (3rd cephalosporin, piperacillin/tazobactam, fluoroquinolone, other beta-lactam)

*It is defined as the case of use or exposure within 30 days prior to onset of bacteremia.

J. Kor. Soc. Health-syst. Pharm. 2021;38:319-30
© 2021 J. Kor. Soc. Health-syst. Pharm.