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Analysis of Clinical Effects of AntithrombinⅢ Supplementation Therapy in Patients with Sepsis-induced Disseminated Intravascular Coagulation
J. Kor. Soc. Health-syst. Pharm. 2019;36:232-243
Published online May 31, 2019;
© 2019 Korean Society of Health-System Pharmacists

Ju Yeon Park, Sun Mi Jung, Myung Hyun Oh, Jae Song Kim and Eun Sun Son

Department of Pharmacy, Severance Hospital, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea
Correspondence to: 손은선 Tel:02-2228-6888
Received February 8, 2019; Revised February 21, 2019; Accepted March 15, 2019.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background : A recent research study published in Japan showed the clinical effects of ATⅢ supplementation therapy in patients with sepsis-induced disseminated intravascular coagulation (DIC). The study found that in-hospital mortality decreased only in the group with ATⅢ activation of 43% or less (HR: 0.603, P=0.045). Based on that study, it would be needed to verify a domestic application standard, starting a supplementation therapy at 70% or less of ATⅢ activity. Hence, this study conducted a retrospective analysis of clinical effects according to ATⅢ activation and suggested the need for a new application standard.
Methods : Data collected from the electronic medical record were divided into two groups based on 43% ATⅢ activation and the data were analyzed for differences in prothrombin time (PT) and platelet improvement, PT and platelet variation, and 28-day mortality.
Results : In 76 sepsis-induced DIC patients who were injected with ATⅢ from January 2015 to December 2017, 35 patients (46.05%) had an ATⅢ activation of 43% or less and 41 (53.95%) were over 43 percent. The number of patients who had PT improvement after ATⅢ supplementation therapy was 16 (45.7%) in the 43% or less ATIII group and 12 (29.3%) in the >43% group (P=0.138). Three patients (8.6%) had platelet improvement in the 43% or less group and three (7.3%) had platelet improvement in the >43% ATIII group (P=1.000). The PT variation was -4.94±7.65 and -3.38±4.89 in the 43% or less and >43% ATIII groups, respectively (P=0.286). The platelet variation was 11.47±30.7 and 6.31±31.86 in the 43% or less and >43% ATIII groups, respectively (P=0.478). The 28-day mortality was 48.6% in the 43% or less ATIII group and 41.5% in the >43% group (P=0.534).
Conclusions : As a result of comparing patients exceeding 43% ATⅢ activation with those below 43%, the frequency of PT improvement and the mean of PT variation showed that the patients with 43% ATⅢ activation or less had a tendency toward improvement on a numerical basis. Accordingly, large-scale, multi-center studies are needed to generate a new domestic application standard for ATⅢ supplementation therapy.
Keywords : AntithrombinⅢ, DIC, ATⅢ activation, Sepsis, Septic shock