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Recent Statistics and Risk Factors of Fentanyl Buccal Tablet Related Opioid Dependence Tendency at a Tertiary Hospital in Korea
J. Kor. Soc. Health-syst. Pharm. 2019;36:476-485
Published online November 30, 2019;  https://doi.org/10.32429/jkshp.2019.36.4.005
© 2019 Korean Society of Health-System Pharmacists

Ahrum Choia, Min Jung Geuma, Jong Hee Koa, Jae Song Kima,b, Eun Sun Sona,b and Kyeng Hee Kwonb,†

Department of Pharmacy, Severance Hospital, Yonsei University Healthcare System, 50 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Koreaa
College of Pharmacy, Dongguk University, Dongguk University Biomedi Campus 32 Dongguk-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 10326, Republic of Koreab
Correspondence to: 권경희 Tel:031-961-5216 E-mail:khkwon@dongguk.edu
Received March 19, 2019; Revised April 25, 2019; Accepted September 20, 2019.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background and Objective : Previous studies on the safety of fentanyl buccal tablets (FBT) have often dismissed patients with a high likelihood of drug abuse or who have been strongly controlled by dose or usage of FBT. For these reasons, we could not confirm the current state of dependence or addiction of opioid pain medication in patients suing FBT in an actual clinical setting. The purpose of this study was to analyze the FBT use status in a tertiary hospital in Korea and the risk factors related opioid dependence tendency and to contribute to the safe use of FBT.
Methods : We retrospectively reviewed electronic medical records of cancer patients admitted to the wards that received FBT at a tertiary hospital in Korea From January to May 2018. The proportion of patients with dependence tendency due to FBT was investigated. Logistic regression analysis was performed to determine the risk factors. The significance level was p<0.05.
Results : Of the total 275 patients, four had FBT dependence tendency, with a ratio of 1.45%. Additionally, smoking history (odds ratio=23.51, p=0.02) and one-day immediate opioid analgesic dose excluding FBT (odds ratio=1.15, p=0.01) were the risk factors for dependence tendency on opioid analgesic due to FBT.
Conclusions : The proportion of patients with dependence tendency due to FBT in a tertiary hospital at Korea was 1.45%, which was higher than the general incidence of dependence or addiction of opioid analgesics used to mitigate cancer pain. Thus, patients taking this drug should be closely monitored for dependence and addiction. Additionally, medical staffs must be fully aware of patients’risk factors. Although this study has limitations as a retrospective study, it may be reliable data for the safe use of opioid analgesic by confirming the dependence tendency and risk factors of FBT in clinical practice.
Keywords : Fentanyl buccal tablet, Opioid dependence, Risk factor


November 2019, 36 (4)