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Suggestions for Pharmacists’ Intervention According to Analysis of Prescription Practices of Contraindicated Drug-Drug Interaction
J. Kor. Soc. Health-syst. Pharm. 2021;38:291-305
Published online August 31, 2021;
© 2021 Korean Society of Health-System Pharmacists

Yoon Wang, Yea Ji Sa, You Kyung Park, Ji Yun Woo, Hye Lim Ahn, Eyn Young Kwon and Jin Suk Kang

Department of Pharmacy, Seoul St. mary’s Hospital, The Catholic University of Korea 222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea
Correspondence to: 왕윤 Tel:02-2258-2527
Received March 29, 2021; Revised April 22, 2021; Accepted July 1, 2021.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background : In Korea, the Health Insurance Review and Assessment Service conducts prospectively inspections on prescription and dispensing for contraindications regarding drug-drug interaction, specific age groups, pregnancy and so forth. When some of contraindicated drug are prescribed, the reason for use must be specified. In 2016, the rate of prescription changes according to DUR contraindicated drug-drug interaction (CDDI) alert was approximately 30%. To find the cause of low prescription change rate, we analyzed the current status of prescriptions of CDDI.
Methods : January to December 2019, we investigated basic information about prescriptions for which the reason is specified despite a CDDI alert at one tertiary hospital. We investigated the severity of the CDDI based on the tertiary literature and suggested clinical intervention for the relatively serious CDDI.
Results : A total of 22,539 cases and 176 kinds of CDDI were prescribed despite a CDDI alert. The number of CDDI cases not administered simultaneously such as metformin-a contrast media was 1,346 (6.0%). The number of CDDI cases of the same efficacy group was 6,220 (27.6%). Also, 8,274 (36.7%) cases of CDDI had relatively low severity (Lexicomp B/C, Micromedex moderate) or no data. The remaining 6,699 cases (29.7%) were recommended to change the prescription according to the tertiary literature (Lexicomp D/X, Micromedex major/contraindicated). The common cases of CDDI were meropenem-valproic acid (554 cases), fluconazole-triazolam (189 cases) and itraconazole-triazolam (134 cases).
Conclusion : The number of CDDI requiring interventions was 69. The intervention plan was suggested for 46 CDDI and recommended (1) changing from one of the drugs to drugs with the similar indication and relatively less drug-interaction, (2) antibiotics was retained and the other drugs were changed because the antibiotic range may be different. In the future, these interventions can be applied to a computer program or used by clinical pharmacists.
Keywords : Contraindicated drug-drug interaction, Pharmacist’s intervention, Drug utilization review

August 2021, 38 (3)